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제 목 Functional Optical Coherence Tomography : Technology and Applications

강 사 Prof. Zhongping Chen

소 속 Department of Biomedical Engineering, Beckman Laser Institute

University of California, Irvine, CA, USA

시 간 2004년 9월 20일 월요일 오후 1시 30분 ~ 2시 30분

장 소 301동 (제 1공학관) 11층 1112호



강사소개

Zhongping Chen received the B.S degree in applied physics from Shanghai Jiaotong University in 1982, an the M.S degree in electrical engineering from Cornell University in 1987, and the Ph.D. degree in applied physics from Cornell University in 1992.

He joined Biological Component Corporation as the Director of Research in 1992 and managed corporate research between 1992-1993. In 1994, he was awarded a National Research Council Associate Fellowship at the Biotechnology Division of the U.S. Army Natick Research, Development Engineering Center. He joined Beckman Laser Institute and Medical Clinic, University of California, Irvine in 1995 and is currently faculty of Biomedical Engineering and Surgery at UCI. His research experience and interests are in the areas of biomedical imaging, photonic materials and devices, biomaterials, and biosensors. His current research foci are the investigation of light/tissue interactions, the development of optical and ultrasound technology for medical diagnosis and treatment, and the integration of advanced optical and semiconductor technology with biotechnology for the development of biomedical devices.



Abstract

Optical coherence tomography (OCT) is a recently developed imaging modality based on coherence-domain optical technology. OCT takes advantage of the short coherence length of broadband light sources to perform micrometer-scale, cross-sectional imaging of biological tissue. OCT is analogous to ultrasound imaging except that it uses light rather than sound. The high spatial resolution of OCT enables noninvasive in vivo "optical biopsy" and provides immediate and localized diagnostic information.

A number of extensions of OCT capabilities for functional imaging of tissue physiology that have been developed in the OCT laboratory at Beckman Laser Institute will be described. Doppler OCT, also named optical Doppler tomography (ODT), combines the Doppler principle with OCT to obtain high-resolution tomographic images of tissuestructure and blood flow simultaneously. Spectroscopic OCT combines spectroscopic analysis with OCT to obtain the depth resolved tissue absorption spectra. Polarization sensitive OCT (PS-OCT) combines polarization sensitive detection with OCT to determinetissue birefringence. Second harmonic optical coherence tomography combines second harmonic generation with coherence gating to obtain images with molecular contrast. These functional extensions of OCT provide clinically important information on tissue physiology, such as tissue blood perfusion, oxygen saturation, hemodynamics, and structural remodeling. Each provides several potential clinical applications, such as vasoactive drug screening, tissue viability and burn depth determination, tumor angiogenesisstudies and cancer diagnosis, bleeding ulcer management, and ocular pathology evaluation. I will review the principle of functional OCT (F-OCT) and highlight some of the results obtained in the OCT Laboratory at the Beckman Laser Institute. New development in light source, imaging method, scanning MEMS probe, and imaging processing algorithm will be discussed.